Novak Djokovic lost to Argentina's Mariano Navone in the first round of the US Open, failing to challenge the record for most major tournament wins in history. This is the first time Djokovic has been eliminated in the first round of a major tournament and the first time since the 2006 Australian Open. Djokovic, who also showed signs of slowing down and cramping during the match, conceded consecutive games from the fourth set onwards, confirming his defeat. On the other hand, other strong players advanced smoothly to the second round.